Institutional Biosafety Committee (IBC)

Biological and biomedical research offers tremendous opportunities for improving our understanding of biological mechanisms and processes and for targeting new and more effective therapies for devastating conditions. At the same time, however, this research involving recombinant DNA, infectious agents, and other potentially hazardous biologics carries inherent safety risks. Working at an appropriate biosafety containment level and with the appropriate safety precautions is essential for mitigating those risks.  

About the Committee

As mandated by the NIH Guidelines, U-M's Institutional Biosafety Committee is responsible for assessing the biosafety containment level for research involving recombinant DNA and synthetic nucleic acid molecules. The U-M Institutional Biosafety Committee (IBC) also oversees research with other potentially hazardous biologics. The U-M IBC currently oversees:

• Recombinant DNA and synthetic nucleic acid molecules (this includes human gene transfer studies)
• Infectious agents pathogenic to humans, animals, and plants
• Biological toxins
• Human-derived tissues, fluids, cells
• Certain animal-derived tissues, fluids, cells (i.e., from non-human primates, ruminants, swine, chickens or other fowl, or wild vertebrate animals)
• Federally-regulated Select Agents and research requiring BSL3 containment

Scope of IBC Authority

The IBC has jurisdiction over research occurring at the University's Ann Arbor, Dearborn, and Flint campuses. The IBC reports to the Vice President for Research, who has authority over this compliance area at U-M, including appointment authority to the committee. 

IBC Charge
IBC Roster

IBC BSL3 Subcommittee

The Vice President for Research has established a BSL3 Subcommittee of the U-M Institutional Biosafety Committee to review proposals that would require the use of BSL3 containment facilities at U-M.  This research may involve federally regulated Select Agents that require special review and oversight of security as well as safety measures. Investigators planning work with Select Agents should contact Janet Follo, the University's Responsible Official, at 734-647-3133 for more information or to initiate the required review processes.

Researcher Roles & Responsibilities

Principal investigators or project directors at U-M are responsible for:

• Understanding the requirements governing research involving potentially hazardous biologics, including recombinant DNA and SNA, infectious agents, biological toxins, human-derived substances, and animal materials.
• Submitting an IBC application to secure required IBC approval before beginning the project.
• Amending the approved IBC application prior to implementing changes to the research.
• Ensuring that all laboratory personnel have received the required training for the work they will perform.
• Adhering to and promoting applicable biosafety procedures, including:
  • Ensuring the use of proper microbiological practices and laboratory techniques at the approved biosafety level
  • If working at BSL2, downloading and compiling a BSL2 Biosafety Manual for use by lab personnel
  • If working at BSL2, scheduling and completing an annual BSL2 laboratory inspection with U-M Environment, Health & Safety (see the EHS Inspection Checklist for details)
• Fulfilling any additional PI/PD responsibilities as detailed in Section IV-B-7 of the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules.

Funding for projects or the transfer of incoming materials may be delayed, pending IBC registration and approval.