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Institutional Biosafety Committee (IBC)

What should I do next?

Working with recombinant DNA or synthetic nucleic acid molecules at BSL1 or BSL2? Register with the IBC

Proposing a human gene transfer project? Obtain NIH/RAC approval as well as review and approval by U-M's IRB and IBC

Biological and biomedical research offers tremendous opportunities for improving our understanding of biological mechanisms and processes and for targeting new and more effective therapies for devastating conditions. At the same time, however, this research involving recombinant DNA, infectious agents, and other potentially hazardous biologics carries inherent safety risks. Working at an appropriate biosafety containment level and with the appropriate safety precautions is essential for mitigating those risks.  

About the Committee:

As mandated by the NIH Guidelines, U-M's Institutional Biosafety Committee is responsible for assessing the biosafety containment level for research involving recombinant DNA and synthetic nucleic acid molecules. The U-M Institutional Biosafety Committee (IBC) also oversees research with other potentially hazardous biologics. The U-M IBC currently oversees:

  • Recombinant DNA and synthetic nucleic acid molecules (this includes human gene transfer studies)
  • Infectious agents
  • Biological toxins
  • Human-derived tissues, fluids, cells
  • Certain animal-derived tissues, fluids, cells
  • Federally-regulated Select Agents, experiments with Dual Use Research of Concern potential, and research requiring BSL3 containment

Scope of IBC Authority

The IBC has jurisdiction over research occurring at the University's Ann Arbor, Dearborn, and Flint campuses, and it may give approval to non-faculty members (i.e., non-UM entities performing work on campus) on a case-by-case basis. The IBC reports to the Vice President for Research, who has authority over this compliance area at U-M, including appointment authority to the committee. 

IBC Charge
IBC Roster

IBC BSL3 Subcommittee

The Vice President for Research has established a BSL3 Subcommittee of the U-M Institutional Biosafety Committee to review proposals that would require the use of BSL3 containment facilities at U-M.  This research may involve federally regulated Select Agents that require special review and oversight of security as well as safety measures. The BSL3 Subcommittee is further designated as the standing Institutional Review Entity required for identification and review of Dual Use Research of Concern (DURC), as specified in the US Government Policy on Institutional Oversight of Life Sciences Dual Use Research of Concern. 

Review of this work is performed by the IBC BSL3 Subcommittee, which operates under a separate charge. Investigators planning work with Select Agents should contact Janet Follo, the University's Responsible Official, at 734-647-3133 for more information or to initiate the required review processes.

Researcher Roles & Responsibilities

Principal investigators or project directors at U-M are responsible for:

Funding for projects or the transfer of incoming materials may be delayed, pending IBC registration and approval.

References and Resources

Other Useful U-M Web Pages

NIH Guidelines

IBC Resources

Laboratory & Research Safety

Questions?

For more information about the IBC, call 734-615-3960 or send e-mail to IBCstaff@umich.edu